NBTI 5463
Product Specifications
CAS Number
1227303-03-8
Target
Antibacterial|||Topoisomerase
Related Pathways
DNA Damage/DNA Repair|||Microbiology/Virology
Bioactivity
NBTI 5463 is a bacterial type II topoisomerase (topoisomerase II) inhibitor with antimicrobial properties. It effectively inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. By binding to topoisomerase II, NBTI 5463 prevents DNA cleavage and re-ligation, thereby impeding bacterial DNA replication and transcription. This compound shows potential for research into Gram-negative bacterial infections.
Smiles
C([C@H](N)[C@]1(CC[C@H](NCC=2N=C3C(=CC2)OCC(=O)N3)CC1)[H])N4C=5C(C=CC4=O)=NC=C(OC)C5
Molecular Formula
C25H30N6O4
Molecular Weight
478.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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