TM471-1
Product Specifications
CAS Number
2649008-95-5
Target
BTK, Apoptosis
Related Pathways
Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
TM471-1 is an orally active, covalent Bruton’s tyrosine kinase (BTK) inhibitor displaying an IC0 value of 1.3 nM for BTKWT, > 40000 nM for BTKC481S, 7.9 nM for TEC, and 12.4 nM for TXK. It inhibits cell growth both in vitro and in vivo, arrests the cell cycle at the G0/G1 phase, and induces apoptosis.
Smiles
C(N)(=O)C=1N2C([C@@H](CCN2)C3CCN(C(C=C)=O)CC3)=NC1C4=CC=C(OC5=CC=CC=C5)C=C4
Molecular Formula
C27H29N5O3
Molecular Weight
471.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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