FLT3-IN-32
Product Specifications
CAS Number
3047195-48-9
Target
FLT|||Apoptosis
Related Pathways
Angiogenesis|||Apoptosis|||Tyrosine Kinase/Adaptors
Bioactivity
FLT3-IN-32 is a potent FLT3 inhibitor with high selectivity, effectively suppressing FLT3 activating mutations and inducing apoptosis. It demonstrates good tolerance in non-tumor-bearing mice. In NOD/SCID mice loaded with MV4-11 cells, FLT3-IN-32 exhibits outstanding antitumor efficacy, significantly extending mouse survival. FLT3-IN-32 is applicable for acute myeloid leukemia research.
Smiles
O=C(NC1=NOC(=C1)C(C)(C)C)NC=2C=CC=3OC(=CC3C2)C(=O)C4=CC=5C(=CC=C(O)C5CN(C)C)N4
Molecular Formula
C28H29N5O5
Molecular Weight
515.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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