SARS-CoV-2-IN-115
Product Specifications
CAS Number
2557232-80-9
Target
Dehydrogenase, DNA/RNA Synthesis, SARS-CoV
Related Pathways
Microbiology/Virology, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Metabolism
Bioactivity
SARS-CoV-2-IN-115 (Compound 3e) is a potent inhibitor of SARS-CoV-2, showing strong antiviral activity in infected Calu-3 cells with an EC50 of 1.7 μM. It effectively inhibits human dihydroorotate dehydrogenase (HsDHODH) activity with an IC50 of 1.5 μM. Importantly, SARS-CoV-2-IN-115 maintains immune response without affecting the proliferation of CD4 T cells.
Smiles
O=C(NC1=CC=C(C#CC2=CC=CC(N)=C2)C=C1)C
Molecular Formula
C16H14N2O
Molecular Weight
250.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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