BT-O2C

Product Specifications

CAS Number

3055107-34-8

Target

Histone Acetyltransferase|||PROTACs|||Epigenetic Reader Domain

Related Pathways

PROTAC|||Chromatin/Epigenetic

Bioactivity

BT-O2C is a highly selective p300 PROTAC degrader that effectively reduces p300 levels in HAP1 cells. It exhibits significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines, with an IC50 of 152-221 nM, and notably decreases the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C is applicable in cancer research.

Smiles

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