AKT-IN-28

Product Specifications

Target

Apoptosis|||PARP|||Caspase|||Akt|||Wnt/beta-catenin

Related Pathways

PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Stem Cells|||Apoptosis|||DNA Damage/DNA Repair|||Proteases/Proteasome|||Cytoskeletal Signaling

Bioactivity

AKT-IN-28 is an allosteric inhibitor of Akt and a derivative of Shikonin. It effectively binds to Akt's allosteric site through hydrophobic and hydrogen bond interactions, with a Kd value of 2.07??M. AKT-IN-28 significantly inhibits Akt activity, inducing apoptosis in KRAS-mutant colorectal cancer cells, arresting the cell cycle at the G2/M phase, and suppressing cell proliferation, migration, and metabolism.