WRN-IN-19
Product Specifications
CAS Number
3058652-58-4
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
WRN-IN-19 (Compound (S) -27) is a covalent WRN helicase inhibitor, with a pIC50 of 5.4 at 0 hours and 7.5 at 4 hours in a DNA-unwinding endpoint assay. It demonstrates synthetic lethality against MSI-H (high microsatellite instability) cancer cells.
Smiles
C(=O)(N1CC2(C1)CCC2)[C@H]3N(C(C=C)=O)CCN(C(CC4=CC=C(C(F)(F)F)C=C4)=O)C3
Molecular Formula
C23H26F3N3O3
Molecular Weight
449.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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