WRN-IN-19
Product Specifications
CAS Number
3058652-58-4
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
WRN-IN-19 (Compound (S) -27) is a covalent WRN helicase inhibitor, with a pIC50 of 5.4 at 0 hours and 7.5 at 4 hours in a DNA-unwinding endpoint assay. It demonstrates synthetic lethality against MSI-H (high microsatellite instability) cancer cells.
Smiles
C(=O)(N1CC2(C1)CCC2)[C@H]3N(C(C=C)=O)CCN(C(CC4=CC=C(C(F)(F)F)C=C4)=O)C3
Molecular Formula
C23H26F3N3O3
Molecular Weight
449.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![TNFRSF18 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI5G4]](https://cdn.genprice.uk/products/937/6868c3d7994c49e6dc3ffc44/imageurl/ta806401am.webp)
TA806401AM 100 µL
TNFRSF18 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI5G4]
Sign In for Pricing
View Details 
BNC940729-100 1x 100 µL
Ku-Holo (p70;83) (KU729), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details