GSK3?-IN-3
Product Specifications
CAS Number
301359-45-5
Target
GSK-3|||Cytochromes P450
Related Pathways
PI3K/Akt/mTOR signaling|||Stem Cells|||Metabolism
Bioactivity
GSK3?-IN-3 is an ATP-competitive GSK-3? inhibitor (IC50= 0.90 ?M) that demonstrates good blood-brain barrier permeability (Pe= 10.7 x 10^-6 cm/s) . It effectively reduces tau protein phosphorylation in the BR5706 strain and decreases A? aggregate deposition in the CL2006 strain, indicating its potential as a candidate for Alzheimer's disease (AD) research.
Smiles
O=C(OCC)C1=C(NC(=S)NC1C=2C=CC=CC2Cl)C
Molecular Formula
C14H15ClN2O2S
Molecular Weight
310.8
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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