LL-K-12-18
Product Specifications
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9977
Bioactivity
LL-K12-18 is a two-site molecular glue that enhances interaction between CDK12 and DDB1, stabilizing the complex and promoting selective degradation of cyclin K with an EC50 of 0.37 nM. It exhibits potent transcriptional repression and antiproliferative effects in tumor models, making it a valuable chemical tool for investigating transcriptional regulation and targeted protein degradation in cancer research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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