LRK-4189
Product Specifications
CAS Number
3063346-83-5
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
LRK-4189 is an orally active, selective PIP4K2C PROTAC degrader with a DC50 <500 nM in MOLT-4 cells. It induces endogenous apoptosis and activates the interferon signaling pathway, exhibiting antitumor activity against microsatellite stable (MSS) colorectal cancer (CRC) cells.
Smiles
FC=1C(C2=CC(=CC=C2)N3C(=O)C=CC=C3)=NC(N[C@@H]4CC[C@@H](NC(=O)[C@@H]5CC[C@H](CC5)N6CCN(CC6)C7=C(F)C=C(N[C@@H]8C(=O)NC(=O)CC8)C=C7)CC4)=NC1
Molecular Formula
C43H49F2N9O4
Molecular Weight
793.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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