MOMA-341
Product Specifications
CAS Number
3078276-74-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
MOMA-341 is a selective, ATP-competitive WRN allosteric inhibitor that binds to the cysteine 727 site of WRN. It induces DNA damage, cell death, and tumor regression in dMMR/MSI-H mouse models and can be used to study advanced and metastatic solid tumors.
Smiles
C(=O)(N1[C@@]2(C3=C(N(N=C3CCN(C(C=C)=O)C2)C4=C(O)C=C(C=C4)C5CC5)CC1)[H])C=6C(N)=C(F)C(C(F)(F)F)=NC6
Molecular Formula
C28H26F4N6O3
Molecular Weight
570.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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