AZD0233

Product Specifications

CAS Number

3036141-78-0

Target

CXCR

Related Pathways

Immunology/Inflammation|||Autophagy|||GPCR/G Protein

Bioactivity

AZD0233 is an orally active CX3CR1 antagonist that immunomodulates the CX3CR1/CX3CL1 signaling axis. It improves cardiac function in dilated cardiomyopathy mouse models while reducing macrophage infiltration and fibrotic scarring.

Smiles

C([C@@H](C)C=1C(F)=CC(OC)=NC1)C=2N=C(N[C@H](CC(C)C)CO)N=C(NS(C)(=O)=O)N2

Molecular Formula

C19H29FN6O4S

Molecular Weight

456.54

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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