HL435
Product Specifications
Target
Epigenetic Reader Domain, PROTACs, Apoptosis
Related Pathways
PROTAC, Chromatin/Epigenetic, Apoptosis
Bioactivity
HL435 is a heterobifunctional molecule that degrades BRD4 by linking with JQ1, with DC50 values of 11.9 nM and 21.9 nM in MDA-MB-231 and MCF-7 cells, respectively. It inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1, and A549 cells, arrests the cell cycle, and induces apoptosis. Additionally, HL435 exhibits antitumor activity in mouse models.
Molecular Formula
C47H48BrClF3N7O7S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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