5-HT1AR agonist 1

5-HT1AR agonist 1 (Compound A3) displays a relatively balanced multi-target activity profile, including 5-HT1AR agonist (EC50= 34 nM), SERT reuptake inhibitor (IC50= 12 nM), NET reuptake inhibitor (IC50= 78 nM), and DAT reuptake inhibitor (IC50= 135 nM) . It demonstrates significant antidepressant effects, excellent bioavailability, and low clearance, making it a promising candidate for research in the field of antidepressant drugs^.