ZG-126
Product Specifications
CAS Number
3049802-32-3
Target
Vitamin, HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Metabolism
Bioactivity
ZG-126 is an agonist of the vitamin D receptor (VDR) and an inhibitor of histone deacetylase (HDAC) with an IC50 range of 0.63-67.6 μM. It demonstrates cytotoxicity in cancer cell lines MDA-MB-231 and 4T1. In mouse models, ZG-126 exhibits antitumor and antimetastatic effects against melanoma and triple-negative breast cancer (TNBC) . Additionally, it shows anti-inflammatory activity by reducing macrophage infiltration and polarization to the immunosuppressive M2 subtype.
Smiles
O=C(NCCCCC(=O)NO)C1=CC=C(C=C1)C(C=2N=C(C(OCC(O)C(C)(C)C)=CC2)C)(CC)CC
Molecular Formula
C29H43N3O5
Molecular Weight
513.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MSM1-102-P1 100ug
Anti-Golgi Complex Antibody Clone 371-4, Unconjugated-100ug
Sign In for Pricing
View Details ![Rabbit Polyclonal Plxdc2 Antibody [Alexa Fluor 647]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
NBP1-76859AF647 0.1 mL
Rabbit Polyclonal Plxdc2 Antibody [Alexa Fluor 647]
Sign In for Pricing
View Details 
abx358241 96 Well
Guinea pig Advanced Glycosylation End Product Specific Receptor (AGER) ELISA Kit
Sign In for Pricing
View Details 32541114 3x 1.0 µg
Olfr1045 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details