Antitumor agent-170
Product Specifications
Target
PARP, PD-1/PD-L1
Related Pathways
Immunology/Inflammation, Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic, Cell Cycle/Checkpoint
Bioactivity
Antitumor agent-170 (Compound C6) inhibits PD-1/PD-L1 interaction and PARP7 with IC50 values of 0.342 μM and 7.05 nM, respectively. It shows high affinity for human PD-L1, with a Ki of 9.31 nM, and can restore T cell function while increasing IFN-γ secretion. In mouse models, Antitumor agent-170 exhibits antitumor effects against melanoma and demonstrates favorable pharmacokinetic properties.
Molecular Formula
C59H69ClF3N11O9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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