Aminoacyl tRNA synthetase-IN-3

Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysyl-tRNA synthetase (PfLysRS) in Plasmodium falciparum with an IC50 value of 59.2 nM. It works by occupying the ATP and L-lysine binding sites of PfLysRS, thereby inhibiting its activity. This compound is a potential candidate for antimalarial drug development.