EpskA21

EpskA21 is an inhibitor of the PI3K/AKT signaling pathway and is capable of suppressing the proliferation of cancer cells including MCF-7, A549, MIA-PaCa-2, Panc-1, and HepG2, with an IC50 range of 1.3-7.24 μM. It can inhibit cell migration, arrest the cell cycle at the G2/M phase in MCF-7 cells and the S phase in MIA-PaCa-2 cells, and induce apoptosis in both MCF-7 and MIA-PaCa-2 cells. EpskA21 also leads to mitochondrial dysfunction.