NZ-66
Product Specifications
CAS Number
3062992-25-7
Target
Mitophagy, Autophagy
Related Pathways
Autophagy
Bioactivity
NZ-66 is a chimeric molecule that targets UNC-51-like kinase 1 (ULK1) to facilitate proximity-induced, ULK1-dependent mitochondrial degradation. It triggers mitophagy (mitochondrial autophagy) and has potential for alleviating neurodegenerative diseases.
Smiles
C(C(NCCCCCCN1C=C(COC2=CC=C([C@H](C(NC3=C(F)C=C(F)C=C3)=O)NC(NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)C=C2)N=N1)=O)(=O)C5=C(NC=6C5=CC=CC6)C7=CC=CC=C7
Molecular Formula
C48H40F8N8O5
Molecular Weight
960.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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