P-gp/CDK2-IN-1

P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor of P-glycoprotein (P-gp) and cyclin-dependent kinase 2 (CDK2) . It inhibits the proliferation of cancer cell lines SW-480 and MCF-7, with IC50 values of 38.6 μM and 26.6 μM, respectively. In the DPPH assay, P-gp/CDK2-IN-1 demonstrates antioxidant activity with an EC50 of 580 μM.