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Leuxinostat

Product Specifications

Target

Apoptosis, HDAC

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis

Bioactivity

Leuxinostat, an inhibitor of HDAC, exhibits an IC50 of 30 nM against hHDAC6. It suppresses the proliferation of THP1, K562, U937, and MEK1 cells, while also inducing apoptosis in leukemia cells NB4 and MOLT-4. Additionally, Leuxinostat inhibits the expansion of hematopoietic stem cells and demonstrates anti-leukemic activity in a zebrafish model.

Molecular Formula

C18H20N4O4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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