Leuxinostat
Product Specifications
Target
Apoptosis|||HDAC
Related Pathways
Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Apoptosis
Bioactivity
Leuxinostat, an inhibitor of HDAC, exhibits an IC50 of 30 nM against hHDAC6. It suppresses the proliferation of THP1, K562, U937, and MEK1 cells, while also inducing apoptosis in leukemia cells NB4 and MOLT-4. Additionally, Leuxinostat inhibits the expansion of hematopoietic stem cells and demonstrates anti-leukemic activity in a zebrafish model.
Molecular Formula
C18H20N4O4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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