PROTAC ALK degrader-1
Product Specifications
CAS Number
3049802-45-8
Target
PROTACs, ALK
Related Pathways
Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors
Bioactivity
PROTACALK degrader-1 (compound B1) is a PROTACs-based ALK degrader with a DC50 of 26 nM in H3122 EML4-ALK. It is utilized in creating PROTACALK degrader-2, which boasts excellent bioavailability.
Smiles
O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCNC(=O)CNC(=O)CN4CCC(C5=CC(OC(C)C)=C(C=C5C)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1
Molecular Formula
C47H55ClN10O9S
Molecular Weight
971.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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