PR280
Product Specifications
Target
Stearoyl-CoA Desaturase (SCD)
Related Pathways
Metabolism
Bioactivity
PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) with an IC50 of 700 nM. It forms hydrogen bonds with amino acid residues of Des1, while its cyclopropenone group may coordinate with the iron center, stabilizing its binding at Des1's active site. This inhibits the ceramide biosynthesis pathway, preventing dihydroceramide (dhCer) from converting into ceramide. PR280 can be used in research related to sphingolipid metabolism disorders, including cancer and metabolic diseases.
Molecular Formula
C27H49NO4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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