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AT1R antagonist 3

Product Specifications

CAS Number

3053482-15-5

Target

Calcium Channel|||RAAS

Related Pathways

Metabolism|||Membrane transporter/Ion channel|||Endocrinology/Hormones

Bioactivity

AT1R antagonist 3 (Compound 1) is an antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 (IC50=0.57 ?M) . It exhibits vasodilatory effects in isolated rat aorta (10 ?M, 88.7%) and shows antihypertensive activity in rat models.

Smiles

O=C(O)C=1C=CC=2N=C(SCC=3C=CC(=CC3)C=4C=CC=CC4C5=NN=NN5)NC2C1

Molecular Formula

C22H16N6O2S

Molecular Weight

428.47

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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