AT1R antagonist 3
Product Specifications
CAS Number
3053482-15-5
Target
Calcium Channel|||RAAS
Related Pathways
Metabolism|||Membrane transporter/Ion channel|||Endocrinology/Hormones
Bioactivity
AT1R antagonist 3 (Compound 1) is an antagonist of the angiotensin II type 1 receptor (AT1R) and an inhibitor of the L-type calcium channel CaV1.2 (IC50=0.57 ?M) . It exhibits vasodilatory effects in isolated rat aorta (10 ?M, 88.7%) and shows antihypertensive activity in rat models.
Smiles
O=C(O)C=1C=CC=2N=C(SCC=3C=CC(=CC3)C=4C=CC=CC4C5=NN=NN5)NC2C1
Molecular Formula
C22H16N6O2S
Molecular Weight
428.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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