SJF-1528 hemihydrate
Product Specifications
Target
PROTACs, EGFR
Related Pathways
Angiogenesis, PROTAC, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
SJF-1528 hemihydrate is the hemihydrate form of SJF-1528. It acts as an EGFR PROTAC degrader, showing activity in OVCAR8 cells with wild-type EGFR and in HeLa cells with exon 20 Ins mutant EGFR, with DC50 values of 39.2 nM and 736.2 nM, respectively. Additionally, SJF-1528 hemihydrate degrades HER2.
Molecular Formula
C55H57ClFN7O8S.1/2H2O
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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