Dicycloplatin
Product Specifications
CAS Number
287402-09-9
Target
DNA/RNA Synthesis, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Apoptosis
Bioactivity
Dicycloplatin is an inducer of DNA damage. It activates doubly phosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1), and triply phosphorylated p53 to induce DNA damage. Dicycloplatin can cause cell cycle arrest, inhibit proliferation, and trigger apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. It is applicable for research in the field of cancer.
Smiles
O=C(O)C1(C(=O)O)CCC1.O=C1[O-][Pt+2]([O-]C(=O)C12CCC2)([NH3])[NH3]
Molecular Formula
C12H20N2O8Pt
Molecular Weight
515.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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