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Naphthol AS-MX phosphate

Product Specifications

CAS Number

1596-56-1

Target

Epigenetic Reader Domain

Related Pathways

Chromatin/Epigenetic

Bioactivity

Naphthol AS-MX phosphate (NASTRp) is a small-molecule inhibitor targeting the CREB (cyclic adenosine monophosphate response element-binding protein) -CBP (CREB-binding protein) transcription factor complex. It exhibits antitumor activity against lung cancer cells by inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchorage-independent growth in soft agar. This compound is valuable for studying KRAS-mutant lung cancer, particularly in cases of chemotherapy resistance and poor prognosis.

Smiles

O=C(NC1=CC=C(C=C1C)C)C2=CC=3C=CC=CC3C=C2OP(=O)(O)O

Molecular Formula

C19H18NO5P

Molecular Weight

371.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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