GT-653
Product Specifications
Target
Histone Demethylase, PROTACs
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
GT-653 is a PROTAC degrader targeting lysine-specific demethylase 5B (KDM5B) . It induces the degradation of KDM5B via ubiquitin-proteasome pathways, achieving a degradation rate of 68.35% at a concentration of 10 μM. Additionally, GT-653 upregulates H3K4me3 levels and activates type I interferon signaling pathways in prostate cancer cells 22RV1.
Molecular Formula
C32H27N7O9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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