PI3Kδ-IN-21
Product Specifications
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
PI3Kδ-IN-21 (Compound 31) is a selective inhibitor of phosphoinositide 3-kinase δ (PI3Kδ), with an IC50 of 13.6 nM. It impedes the proliferation and differentiation of T cells through the PI3K/AKT/mTOR signaling pathway. In rat models, PI3Kδ-IN-21 exhibits favorable pharmacokinetic properties and demonstrates activity in improving experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein (MOG) in EAE models.
Molecular Formula
C19H16ClN9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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146140 100 µg
PRDM1, CT (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, BLIMP1, MGC118922, MGC118923, MGC118924, MGC118925)
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