Phosphodiesterase-IN-2
Product Specifications
CAS Number
3047610-96-5
Target
PDE
Related Pathways
Metabolism
Bioactivity
Phosphodiesterase-IN-2 (Compound C7) is an orally active and selective inhibitor of phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. It enhances hepatic microsomal stability and reduces blood-brain barrier permeability. Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties in mouse models and can alleviate isoprenaline-induced cardiac hypertrophy.
Smiles
O=C(C1=CC(=NC=2C=CC=CC21)COC3=CC=C(C=C3)N4N=C(C=C4C=5C=CN=C(C5)C)C(F)(F)F)N6CC7(CNC7)C6
Molecular Formula
C32H27F3N6O2
Molecular Weight
584.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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