TGFβRII-IN-3
Product Specifications
CAS Number
2351149-20-5
Target
TGF-beta/Smad
Related Pathways
Stem Cells
Bioactivity
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) with an IC50 of 4.1 μM. It inhibits TGFβ signaling by promoting protein degradation of TGFβ RII. Additionally, TGFβRI-IN-7 can block the transition from endothelial to mesenchymal states and inhibit cell migration, making it useful for cancer research.
Smiles
O=C(C=1C=2C(=O)CC(C)(C)CC2NC1C)N(C)CC3=CC=CC(=C3)C4=CC=C(C=C4)C(F)(F)F
Molecular Formula
C27H27F3N2O2
Molecular Weight
468.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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