NF-?B-IN-16

NF-?B-IN-16 (compound 9) is a complex of an NF-?B inhibitor and Cisplatin (Pt (IV) complex) with potent and low-toxicity antitumor activity. It can cause DNA damage, induce mitochondrial dysfunction, generate reactive oxygen species, and trigger apoptosis via mitochondrial pathways and endoplasmic reticulum stress. NF-?B-IN-16 effectively inhibits the NF-?B/MAPK signaling pathway and disrupts PI3K/AKT signal transduction. Additionally, it demonstrates excellent in vivo antitumor efficacy and low toxicity in A549 or A549/CDDP xenograft models.