RTx-152
Product Specifications
CAS Number
3035072-48-8
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
RTx-152 is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM) that targets Polθ captured on DNA. It selectively kills cancer cells with homologous recombination (HR) defects and inhibits resistance to PARP inhibitors across various genetic backgrounds, including HR-proficient cells. Additionally, RTx-152 selectively eliminates BRCA2-deficient cells.
Smiles
O=C(OC=1C(=CC(=CC1C(F)(F)F)C(F)(F)F)N2C(=O)N(C)CC2)N(C3=CC=C(F)C=C3)C
Molecular Formula
C20H16F7N3O3
Molecular Weight
479.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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