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RTx-161

Product Specifications

Target

Apoptosis, DNA/RNA Synthesis

Related Pathways

Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. It selectively kills HR-deficient cancer cells and inhibits PARP inhibitor (PARPi) resistance across various genetic backgrounds, including HR-proficient cells. RTx-161 also induces apoptosis.

Molecular Formula

C21H18F7N3O4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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