RTx-161
Product Specifications
Target
Apoptosis, DNA/RNA Synthesis
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Bioactivity
RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. It selectively kills HR-deficient cancer cells and inhibits PARP inhibitor (PARPi) resistance across various genetic backgrounds, including HR-proficient cells. RTx-161 also induces apoptosis.
Molecular Formula
C21H18F7N3O4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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