IOX5

Product Specifications

Target

HIF/HIF Prolyl-Hydroxylase|||Apoptosis

Related Pathways

Chromatin/Epigenetic|||Apoptosis|||Metabolism

Bioactivity

IOX5 is a selective prolyl hydroxylase (PHD) inhibitor with an IC50 of 0.19 ?M for PHD2. In acute myeloid leukemia (AML) cells, IOX5 can stabilize HIF-1?, inhibit cell proliferation, and induce apoptosis. It exhibits anti-leukemia activity.

Molecular Formula

C17H19F3N4O2

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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