SIK-IN-3
Product Specifications
Target
AMPK
Related Pathways
Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling
Bioactivity
SIK-IN-3 (Compound 6B) is an inhibitor of salt-induced kinases (SIK), demonstrating inhibitory effects on SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.3, and 0.8 nM respectively. SIK-IN-1 inhibits TNFa release in human macrophages with an IC50 of 0.6 nM and stimulates LPS-induced IL-10 release with an EC50 of 3 nM.
Molecular Formula
C24H25N5OS
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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