Transthyretin-IN-3

Transthyretin-IN-3 (compound 6) is a synthetically designed benzofuran analogue. It selectively binds with transthyretin in plasma, inhibiting amyloid aggregation with an IC50 of 5.0±0.2 μM. By incorporating a chlorine substituent at a specific position, Transthyretin-IN-3 effectively targets the thyroxine binding site of TTR, preventing the dissociation of TTR tetramers into unstable monomers.