Gal-ARV-771
Product Specifications
Target
PROTACs, Apoptosis, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, Apoptosis, PROTAC
Bioactivity
Gal-ARV-771 is a PROTAC prodrug, modified with galactose, based on ARV-771. It is activated in senescent cancer cells that express SA-β-Gal, thereby releasing ARV-771. Through the ubiquitin-proteasome pathway, Gal-ARV-771 induces selective degradation of the BRD4 protein in senescent cells and promotes apoptosis (apoptosis) of these cancer cells.
Molecular Formula
C71H84ClN9O19S2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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