HER2-IN-17

HER2-IN-17 (Compound 2) is an inhibitor of HER2 that effectively targets the YVMA HER2 exon 20 insertion mutation (HER2 YVMA), with an IC50 of less than 200 nM. It also impedes the proliferation of HER2 YVMA mutant BaF3 cells, with an IC50 below 200 nM, and contributes to improvements in non-small cell lung cancer (NSCLC) .