α-Amylase/α-Glucosidase-IN-10

α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 30.39 μM and 65.1 μM, respectively, indicating potential antidiabetic properties. In ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions, it shows high gastrointestinal (GI) absorption but functions as a substrate for P-glycoprotein (P-gp) and does not cross the blood-brain barrier (BBB), which may pose a risk of central nervous system side effects.