What is the catalog number for PRMT5/EGFR-IN-1?

The catalog number for PRMT5/EGFR-IN-1 is T209477.

What sizes are available for PRMT5/EGFR-IN-1?

PRMT5/EGFR-IN-1 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does PRMT5/EGFR-IN-1 come in?

PRMT5/EGFR-IN-1 is available in 2 different pack sizes.

Is PRMT5/EGFR-IN-1 in stock?

PRMT5/EGFR-IN-1 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PRMT5/EGFR-IN-1?

PRMT5/EGFR-IN-1 is manufactured by Molfinity.

What is the estimated delivery time for PRMT5/EGFR-IN-1?

Estimated delivery time for PRMT5/EGFR-IN-1 is approximately 10 business day(s), depending on your location.

PRMT5/EGFR-IN-1

Product Specifications

Target

EGFR, Histone Methyltransferase

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, JAK/STAT signaling

Bioactivity

PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 μM and 19.31 μM, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.