PRMT5/EGFR-IN-1
Product Specifications
Target
EGFR|||Histone Methyltransferase
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling
Bioactivity
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual inhibitor targeting PRMT5 and EGFR, with IC50 values of 15.47 ?M and 19.31 ?M, respectively. It demonstrates antiproliferative activity against the A549, MCF7, HeLa, and MDA-MB-231 cell lines. This compound also exhibits favorable pharmacokinetic (PK) and pharmacodynamic (PD) properties in vivo and significantly inhibits the growth of MCF7 orthotopic xenograft tumors.
Molecular Formula
C27H22F6N2O2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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