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AurkA allosteric-IN-1

Product Specifications

Target

Aurora Kinase

Related Pathways

Cell Cycle/Checkpoint|||Chromatin/Epigenetic

Bioactivity

AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor with an IC50 of 6.50 ?M, which inhibits both the catalytic and non-catalytic activities of Aurora A. Aurora A is involved in the regulation of bipolar mitotic spindle assembly and the fidelity of chromosome segregation during mitosis. AurkA allosteric-IN-1 interferes with Aurora A by binding to the Y-pocket, thereby preventing its interaction with the activator TPX2.

Molecular Formula

C20H16N2O3

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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