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PROTAC GSK-3? Degrader-1

Product Specifications

Target

GSK-3|||PROTACs

Related Pathways

PI3K/Akt/mTOR signaling|||Stem Cells|||PROTAC

Bioactivity

PROTACGSK-3? Degrader-1 (compound 1) is a degrader targeting GSK-3? with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3? inhibitor), a PEG linker, and CRBN (E3 ligase ligand) . It reduces neurotoxicity induced by A?25-35 peptide and CuSO4 and is applicable in Alzheimer's disease research.

Molecular Formula

C43H42Cl2N6O9

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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