Tubulin/HDAC-IN-4
Product Specifications
Target
Microtubule Associated|||Apoptosis|||Reactive Oxygen Species|||HDAC
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||Metabolism|||NF-?B|||Immunology/Inflammation|||DNA Damage/DNA Repair|||Cytoskeletal Signaling
Bioactivity
Tubulin/HDAC-IN-4 (compound 9n) is a dual inhibitor targeting microtubules (Tubulin) and HDAC, exhibiting IC50 values of 0.73, 0.43, 0.62, and 2.34 µM for HDAC1, HDAC2, HDAC6, and HDAC7, respectively. It disrupts microtubule assembly by binding to the colchicine site and induces apoptosis and G2/M cell cycle arrest. Additionally, Tubulin/HDAC-IN-4 significantly increases intracellular ROS levels and demonstrates both anti-angiogenic and anticancer properties.
Molecular Formula
C24H26N2O6
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/372420505971458094/T209426
Available Sizes
Curated Selection
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