PROTAC BTK Degrader-9
Product Specifications
Target
RANKL/RANK|||BTK|||PROTACs
Related Pathways
PROTAC|||Tyrosine Kinase/Adaptors|||NF-?B|||Angiogenesis
Bioactivity
PROTACBTK Degrader-9 (compound 23) is a potent PROTACs degrader that specifically targets BTK. It effectively downregulates the RANKL-activated BTK-PLC?2-Ca2+-NFATc1 signaling pathway. Consequently, PROTACBTK Degrader-9 inhibits osteoclastogenesis and reduces alveolar bone resorption in a mouse model of periodontitis.
Molecular Formula
C46H52FN13O5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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