Polθ/PARP-IN-1
Product Specifications
Target
DNA/RNA Synthesis, PARP, Apoptosis
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
Polθ/PARP-IN-1 (compound 25d) is a potent dual inhibitor of DNA polymerase theta (Polθ) and PARP, with IC50 values of 45.6 nM and 5.4 nM, respectively. This compound exhibits antiproliferative activity, induces apoptosis and cell cycle arrest at the G2/M phase, leading to DNA damage, and demonstrates antitumor properties.
Molecular Formula
C38H33ClFN7O5S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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